Imperfect Genetic Engineering

Genetic engineering (aka genetic modification) involves changing of an organism’s genome using biotechnology. This is being explored in cell & gene therapy where this technique can help in the 1) correction of a genetic disorder, 2) enhancing healing/regenerative properties or 3) using these cells to target cancer like a trojan horse. ⠀
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The process of inserting genes🧬into cells is known as transfection. During this process, not all cells will be transfected & researchers may have to select the transfected ones for further studies.

Reference

Scientific American “Gene Therapy Arrives” (1 Jan 2020)

FDA “Cellular & Gene Therapy Products” (20 Jun 2019)

Nature “Stem-cell and genetic therapies make a healthy marriage” (15 May 2019)

“Recent challenges and advances in genetically-engineered cell therapy” Journal of Pharmaceutical Investigation (28 Dec 2017)

“Selection of Transfected Mammalian Cells” Current Protocols in Molecular Biology (1 Apr 2009)